KONG, ZWE LING,龚瑞林,龔瑞林,KO, FAN CHI,柯泛其,柯汎其,YEH, AI LING,叶艾灵,葉艾靈
申请号：
TW103118983
公开号：
TW201522358A
申请日:
2014.05.30
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Use of an active compound in the manufacture of a medicament for increasing the expression of SIRT1 mRNA, and/or decreasing the expression of SOCS3 mRNA, and especially for regulating blood glucose levels, wherein the active compound is selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and combinations thereof, wherein X is H or C1-C3 alkyl one of Y and Z is and another is , wherein when Y is is and R1 to R13 are independently H or OH, and wherein R1 to R3 are not simultaneously H R8 and R9 are not simultaneously H.一種使用一活性成分於製備藥劑之用途,其中該藥劑係用於增加SIRT1 mRNA表現量及/或降低SOCS3 mRNA表現量,尤其可用於調節血糖,且該活性成分係選自以下群組:式(I)化合物、式(I)化合物之醫藥可接受鹽、及前述之組合,其中,X為H或C1-C3烷基;Y及Z之一者為另一者為H、OH或,其中當Y為時,Z為;以及R1至R13係各自獨立為H或OH,且其中,R1至R3不同時為H;R8及R9不同時為H。
