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5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES FOR TREATING BACTERIAL INTESTINAL DISEASES
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
HUBSCHWERLEN, CHRISTIAN,LOCHER, HANS
申请号:
NZ58973409
公开号:
NZ589734A
申请日:
2009.05.08
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
The disclosure relates to the compounds of formula I (I) wherein A is N or CH; and n is 0 or 1; or the pharmaceutically acceptable salts thereof, for preventing or treating intestinal diseases which are caused by bacteria selected from Clostridium difficile, Clostridium perfringens or Staphylococcus aureus. Examples of these compounds include: 1-cyclopropyl-6-fluoro-7-{ 4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl} -4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; 1-cyclopropyl-6-fluoro-7-{ 4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)phenoxymethyl]-4-hydroxy-piperidin-1-yl} -4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and 1-cyclopropyl-6-fluoro-7-{ 3-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-3-hydroxy-pyrrolidin-1-yl} -4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.
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中国工程科技知识中心
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