SONG, YEN LING,宋延龄,宋延齡,T. A. JOSE, PRIYA,卜 莉亚,卜 莉亞,LIN, YEN HONG,林彦宏,林彥宏
申请号：
TW100134509
公开号：
TW201313247A
申请日:
2011.09.26
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention provides an optimized immobilization antigen cDNA sequence of cryptocaryon irritans, which has been processed codon replacement and caused the cDNA to express in prokaryotic and eukaryotic cell and translate a protein has similar immunogenicity as the immobilization antigen purified from the thereon of Cryptocaryon irritans. The present invention further provides a DNA vaccine produced using the cDNA to prevent fish form cryptocaryon irritans infection.本發明提供一種優化(optimize)海水白點蟲制動抗原互補去氧核糖核酸(cDNA)序列,其係透過置換密碼子使該序列能於原核生物及真核生物中表現,並且能產生免疫原性與海水白點蟲纖毛幼蟲純化出之制動抗原相近之蛋白質。本發明該進一步提供一以該cDNA製造之DNA疫苗預防魚類受海水白點蟲感染。
