PROBLEM TO BE SOLVED: To provide a novel method for treating cancer.SOLUTION: According to the present invention, there is provided a combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and a method for use thereof, including a method for treating conditions or delay of progression where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or delay of progression. Preferably, the PD-1-binding antagonist may be an antibody, MDX-1106, Merk 3745, CT-011, or AMP-224.SELECTED DRAWING: Figure 8【課題】新規、がんの治療方法の提供。【解決手段】ＰＤ-１軸結合アンタゴニストとＭＥＫ阻害剤を含む併用療法と、癌の治療又は進行の遅延のための腫瘍免疫原性の増大のような免疫原性の増大が所望される症状を治療又はその進行の遅延する方法を含むその使用方法。好ましくは、ＰＤ－１結合アンタゴニストが、抗体、ＭＤＸ－１１０６、メルク３７４５、ＣＴ－０１１又はＡＭＰ－２２４である、方法。【選択図】図８
