Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof

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专利权人:

Sridhar Mani

发明人:

Sridhar Mani,Bhaskar C. Das

申请号：

US12735368

公开号：

US08669260B2

申请日:

2009.01.27

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.

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