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Highly compactable and durable direct compression excipients and excipient systems
专利权人:
John Tillotson;Cecil Propst
发明人:
John Tillotson,Cecil Propst
申请号:
US12661016
公开号:
US08617588B2
申请日:
2010.03.09
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.
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