A wireless detection system of physiological signals is provided for wirelessly transmitting variation values of physiological signals, and includes a wireless detecting notification device and a wireless transceiver display device. The wireless detecting notification device comprises at least one transplantable sensor, a connecting line, a printed circuit board, a wireless communication micro-processor chip, an antenna and a power integration module. The power integration module includes a power management chip, a wireless charging coil and a chargeable battery, for integrating a power supply of the wireless detecting notification device. Further, a wireless detection method of physiological signals is further provided to detect variation values of physiological signals in organs of an organism. After calculating and analyzing the variation values of physiological signals, identifying an analyzed result for determining to store the variation values or to wirelessly transmit an alarm signal to the wireless transceiver display device.
