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TREATMENT OF OCULAR DISEASES WITH FULLY-HUMAN POST-TRANSLATIONALLY MODIFIED ANTI-VEGF FAB
专利权人:
REGENXBIO INC.;THE JOHNS HOPKINS UNIVERSITY
发明人:
YOO, Stephen,REINHARDT, Rickey,VAN EVEREN, Sherri,KOZARSKY, Karen,SIMPSON, Curran,WU, Zhuchun,CAMPOCHIARO, Peter,SHEN, Jikui,DING, Kun
申请号:
SG11202002396T
公开号:
SG11202002396TA
申请日:
2018.09.26
申请国别(地区):
SG
年份:
2020
代理人:
摘要:
Compositions and methods are described for the delivery of a fully human post- translationally modified (HuPTM) monoclonal antibody ("mAb") or the antigen-binding fragment of a mAb against human vascular endothelial growth factor ("hVEGF") - such as, e.g., a fully human-glycosylated (HuGly) anti-hVEGF antigen-binding fragment - to the retina/vitreal humour in the eye(s) of human subjects diagnosed with ocular diseases caused by increased neovascularization, for example, neovascular age-related macular degeneration ("nAMD"), also known as "wet" age-related macular degeneration ("WAMD"), age-related macular degeneration ("AMD"), and diabetic retinopathy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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