Molecules and compositions are described for use in the treatment and prevention of pro- inflammatory conditions. HDL-related molecules, including ApoA-I, bovine HDL and HDL mimetics, in particular, are demonstrated to prevent UV- induced cell death and oxidative stress in skin cells and to inhibit tumor growth and development in a variety of cancers. HDL-related molecules can be used as an oral supplement and in other compositions to prevent or treat pro- inflammatory skin conditions and systemic proinflammatory conditions, including Alzheimers disease and various cancers.
