MERCK SHARP & DOHME CORP.;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.
发明人:
申请号：
ARP120103284
公开号：
AR087791A1
申请日:
2012.09.06
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. The substance refers to the formula compound (1) used as NS5B polymerase inhibitor of hepatitis C virus (VHC)；to the synthesis of such compounds, and to the use of such compounds for the inhibition of HCV NS5B polymerase activity, for the treatment or prevention of HCV infections and for the inhibition of HCV viral replication and / or the viral production in a cell based system. Claim 1: A compound having the formula (1) or a pharmaceutically acceptable salt thereof, wherein: A is 5 or 6 membered monocyclic heteroarylene, which is optionally substituted with up to 4 groups, which may be the same or different, and are selected from halo, hydroxy, C₁₋₆ alkyl,-O- (C₁₋₆ alkyl),C₁₋₆ haloalkyl,-S (O) ₂- (C₁₋₆ alkyl),5-6 members of single ring heterosexual, 9-10 members of double ring heterosexual, n (r830909) 832222；-No.8322；-O- (C₁₋₆ alkylene) -C (O) OR⁵,Y-cn, in this single ring heteromorphic group composed of 5 or 6 members, you can choose a ring carbon atom derived from one ring carbon group； B is a double ring heteromorphic group composed of 8 to 10 members, with 1 to 4 heteromorphic atoms in the ring, each member can choose independently between N and s, Among them, this group of 8-10 members can be replaced by up to 4 r758080 members；which may be the same or different, and are selected from: a) halogen, b) OH c) C₁₋₆ alkyl,d) O (alquilo C)e) CN, f) (CH₂) ₀₋₃-ArB, in which each ArB is an aromatic ring system independently selected from the group consisting of: i) monocyclic rings of 5 or 6 members with 0, 1, 2 , 3 or 4 heteroatomic ring atoms independently selected from the group consisting of N, O or S, and ii) 8, 9 or 10 member bicyclic rings with 0, 1, 2, 3 or 4 heteroatomic ring atoms independently selected from the group consisting of N, O or S, g) (CH₂) ₀₋₃NRᵈC (O) Rᵉ,h) (CH) NR SO Ri) (CH₂) ₀₋₃C₍O₎NRᵈRᵉ,j) (CH) SO R(k) O'832222 (rent c8321)l) -C (O) OR(m) Yes (r8321) 8321；wherein the following Rᶜ groups: c) C₁₋₆ alkyl,d) O (alquilo C)and f) (CH₂) ₀₋₃-ArB,
