ANDERS JOHANSSON;JOACHIM PERSSON;ALBIREO AB;ASTRAZENECA AB
发明人:
ANDERS JOHANSSON,JOACHIM PERSSON
申请号：
IL17189405
公开号：
IL171894A
申请日:
2005.11.10
申请国别(地区):
IL
年份:
2012
代理人:
摘要：
The present invention relates to a compound of the general formula (I) wherein Het is an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring having at least one nitrogen atom； R1 is hydrogen, hydroxy, C<；SUB>；1<；/SUB>；-C<；SUB>；4 <；/SUB>；alkyl, C<；SUB>；3<；/SUB>；-C<；SUB>；4 <；/SUB>；cycloalkyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkenyl or C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkynyl； R2 and R3 is each and independently selected from hydrogen, C<；SUB>；1<；/SUB>；-C<；SUB>；4 <；/SUB>；alkyl, C<；SUB>；3<；/SUB>；-C<；SUB>；4 <；/SUB>；cycloalkyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkenyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkynyl, C<；SUB>；1<；/SUB>；-C<；SUB>；4 <；/SUB>；alkoxy, halogen and cyano, provided that R2 and R3 may not both be hydrogen； R4 is C<；SUB>；1<；/SUB>；-C<；SUB>；4 <；/SUB>；alkyl, C<；SUB>；3<；/SUB>；-C<；SUB>；4 <；/SUB>；cycloalkyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkenyl or C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkynyl； Ar is an optionally substituted aromatic ring system selected from pyridinyl； 1-naphthyl； 5,6,7,8-tetrahydro-1-naphthyl； quinolinyl； 2,3-dihydro-1,4-benzodioxinyl； 1,3-benzodioxolyl； 5,6,7,8-tetrahydroquinolinyl； 5,6,7,8-tetrahydroisoquinolinyl； 5,6,7,8-tetrahydroquinazolin-4-yl； 1-benzo[b]thiophen-7-yl； 1-benzo[b]thiophen-4-yl； 1-benzo[b]thiophen-3-yl； isoquinolinyl； quinazolinyl； and indan-4-yl； or Ar is substituted phenyl； or an enantiomer thereof or any salt thereof； to a pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of compounds of formula I and to new intermediates used in the preparation thereof.
