The present invention is directed to valvuloplasty catheter balloons and balloon catheters for valvuloplasty with such catheter balloons coated with at least one layer containing at least one antiproliferative, immunosuppressive, anti-angiogenic, anti-inflammatory, anti-restenotic and/or anti-thrombotic agent and a top coat consisting of a polyvinyl alcohol-polyethylene glycol graft copolymer as well as the use of these balloon catheters for the prevention of restenosis after valvuloplasty.