The present invention relates to an antibody which hasa therapeutic effect on cancer, an autoimmune disease, or aninflammatory disease. That is, the present invention relatesto an antibody which exhibits a cytotoxic activity againstdeath domain-containing receptor-expressing cells throughapoptosis.[Object]An object of the invention is to provide a pharmaceuticalhaving a therapeutic effect on cancer.[Means for Resolution]A novel anti-DR5 antibody capable of inducing apoptosisin cells has more potent cytotoxic activity than currentlyavailable anti-DR5 antibodies.[Selected Drawing]None
