An interventional medical device that incorporates an imaging system may be minimally invasive and equipped with an anchoring portion at a proximal end for securing the device to a human body. A luer lock may be utilized at the proximal end, for example, for introducing a syringe. The medical device can be in the form of sheaths, catheters, and interventional devices, particularly those suitable for minimally invasive procedures in the pericardium. The imaging system comprises one or more ultrasound transducers and can be used to guide the device to a target area and to perform a procedure and/or provide access to a target area for performing a procedure via a plurality of lumen. In one embodiment, a micro-electro-mechanical system may be utilized to monitor pressure within a human body.