SUBSTITUTED 2-THIOXO-IMIDAZOLIDIN-4-ONES AND SPIRO ANALOGUES THEREOF, ACTIVE ANTI-CANCER INGREDIENT, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION, METHOD FOR TREATING PROSTATE CANCER
The invention relates to novel (R)-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1, or spiro analogues thereof, which exhibit androgen receptor antagonist properties, variants of a method for producing same, and intermediate compounds for producing compounds of formula 1. Compounds of formula 1 can be used to produce a medicinal agent suitable for treating cancers, such as prostate cancer and breast cancer. The invention also relates to a pharmaceutical composition in the form of tablets, capsules and injections. In formula 1, R1 is OH, NH2 or an OR4 group R2 and R3 are methyl, or R2 and R3 are a ??2-??2 group and R4 is ?1-?4 alkyl or cyclopropyl.
