Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration. Also, provided herein are methods for promoting skin regeneration and wound healing. The present invention relates generally to skin regeneration and wound healing, and more specifically, to small molecule-mediated induction of dermal human fibroblast proliferation and increased protein production.
