Adjunct materials for delivery to colon tissue are provided. In general, the adjunct materials can be configured to be delivered to colon tissue by deployment of staples from a cartridge body of a surgical stapler to form at least one line of deployed staples. The adjunct material can be formed of a fiber matrix and include an effective amount of one or more medicants for delivery to the colon tissue. The medicant is disposed within and releasable from the adjunct material, and effective to encourage a desired effect on blood vessels, such as angiogenesis and/or vasodilation, along the at least one line of deployed staples. Methods of using a staple cartridge assembly or an end effector to apply such adjunct materials to colon tissue are also provided.
