PATHI, SRINIVAS LAXMINARAYAN,RAO, DHARMARAJ, RAMACHANDRA,KANKAN, RAJENDRA, NARAYANRAO,PUPPALA, REVIKUMAR,GANGRADE, MANISH,KANATHALA, SHASHIREKHA
申请号：
NZ57692907
公开号：
NZ576929A
申请日:
2007.11.13
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is crystalline anhydrous form C of moxifloxacin hydrochloride characterised by having an XRPD with peaks at 10.24, 15.08, 17.21, 24.60, 25.06, 26.42, 27.86, 28.22, 28.88 and 29.85 ± 0.2 °2q, and which also exhibits a melting endotherm peak at 253°C as measured by differential scanning calorimetry (10.00 ºC/minute). Further disclosed is a method of making moxifloxacin hydrochloride form C as defined above which comprises dissolving or suspending moxifloxacin base in methanol treating the solution with methanolic hydrochloric acid isolating the resulting moxifloxacin hydrochloride and drying said moxifloxacin hydrochloride under vacuum at 80 - 90°C to obtain Form C.
