PROBLEM TO BE SOLVED: To provide a method for safely and efficiently mass-producing a sesamin hydrolyzate having amyloid formation inhibition activity and an amyloid formation inhibitor composed of a sesamin hydrolyzate obtained by the method as an active ingredient.SOLUTION: The method for producing a sesamin hydrolyzate includes hydrolyzing sesamin derived from sesame seed with water in a subcritical state so that a mixture of sesame and water has an arrival temperature of 200-350°C. The method for producing a sesamin hydrolyzate includes a first process and a second process. The first process is a process for mixing sesamin derived from sesame seed with water, hermetically sealing the mixture in a pressure-resistant container, heating the container so that the mixture in the pressure-resistant container has an arrival temperature of 200-350°C and keeping the container at the temperature for 0-120 minutes. The second process is a process for cooling a hydrolyzate formed in the pressure-resistant container and taking out the hydrolyzate from the pressure-resistant container using a solvent.COPYRIGHT: (C)2012,JPO&INPIT【課題】アミロイド形成阻害活性を有するセサミン分解物を安全に且つ効率的に量産できる方法及びこの方法によって得られるセサミン分解物を有効成分とするアミロイド形成阻害剤を提供する。【解決手段】ゴマ種子由来のセサミンを到達温度が200~350℃の亜臨界状態の水で加水分解した。【選択図】なし
