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INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS
专利权人:
Michael Weiss
发明人:
Michael Weiss
申请号:
US13515192
公开号:
US20120277148A1
申请日:
2010.12.13
申请国别(地区):
US
年份:
2012
代理人:
摘要:
An insulin analogue comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The chlorinated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Chlorine substitution-based stabilization of insulin may reduce fibrillation and thereby enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration.
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