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Peripheral administration of proteins including TGF-beta superfamily members for systemic treatment of disorders and disease
专利权人:
STRYKER CORPORATION
发明人:
GOAD, MARY ELIZABETH PECQUET,HASKELL, MELISSA M.,SCHRIER, DENIS,WOOD, SUSAN A.
申请号:
AU2010213575
公开号:
AU2010213575B2
申请日:
2010.02.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-&bgr; superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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