VAN DUN, CORNELIS MARIA PETRUS,MOVAHEDI, SARA,DE JOODE, JAPSER,FRIJTERS, RAOUL JACOBUS JOHANNES MARIA,HAARING, CORNELIS,BAL, ERIC CORNELIS JOSEPHUS
申请号：
CA2943388
公开号：
CA2943388A1
申请日:
2015.04.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to modified RDR1 gene capable of conferring virus resistance to a plant and/or increasing virus resistance in a plant, which modification results in enhanced expression of the RDR1 gene, and wherein the modification is selected from a modification that increases the mRNA level of the RDR1 gene； a modification that increases the level of the RDR1 protein； and/or a modification that increases the activity of the RDR1 protein, as compared to a non-modified wild-type RDR1 gene. The modification may comprises a modification upstream of the coding sequence of the RDR1 gene, such as a modification of a regulatory element, preferably of a cis-acting regulatory element. The modified regulatory element is for example selected from a transcription factor binding site for a transcriptional repressor, the modification of which leads to reduction or absence of transcriptional repression； and/or a transcription factor binding site for a transcriptional activator, the modification of which leads to induction or enhancement of transcription； and/or a microRNA binding site, the modification of which leads to reduction or absence of gene repression； and/or a small RNA sequence, the modification of which leads to reduction or absence of gene repression.
