HE, KAN,ROLLER, MARC,BILY, ANTOINE,IBARRA, ALVIN,BAI, NAISHENG,DIKANSKY, JACQUES
申请号：
CA2704640
公开号：
CA2704640C
申请日:
2008.11.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A Fraxinus excelsior seed extract that can be administered for therapeutictreatment of a subject, including ahu-man, by blocking fat synthesis, activating PPAR-alpha, increasinghypoglycemic activity, reducing bodyweight, controlling fastingplasma insulin levels against hyperinsulinemia, and promoting insulinsensitivity and causing a beneficial acute insulinotropiceffect. The Fraxinus excelsior seed extract includes, inter alia, an isolatedcompound (2S, 3E, 4S)2H-Pyran-4-acetic acid-3-ethyli-dene-2-[(6-O-.beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonlycalledex-celside A, an isolated compound (2S, 3E, 4S)2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- .beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4-hydroxyphenyl) ethyl ester, commonly called excelside B, and thecompoundsGI5, GI3, nuzhenide, and oleoside dimethyl ester.
