#$%^&*AU2013207589B220160407.pdf#####Abstract Provided is a pharmaceutical composition for treating and/or preventing abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like. FP1021s WGA/FP1021s/PN797709/English translation of PCT specification/2.6.2011 2938774-1-warends