Provided are a method for evaluating or selecting a sensory-stimulation-reducing agent for reducing sensory stimulation using parabens, and a sensory-stimulation-reducing agent for reducing sensory stimulation using parabens. A method for evaluating or selecting an agent for reducing sensory stimulation using parabens that includes the following steps (1)-(3). (1) A step for bringing a test substance into contact with cells capable of expressing CES1. (2) A step for measuring CES1 expression in said cells. (3) A step for evaluating a test substance that promotes expression of CES1 as an agent for reducing sensory stimulation using parabens on the basis of the results measured in (2).本發明提供一種對降低因對羥苯甲酸酯類所致之感覺刺激之感覺刺激低減劑進行評估或選擇之方法、及降低因對羥苯甲酸酯類所致之感覺刺激之感覺刺激低減劑。本發明之因對羥苯甲酸酯類所致之感覺刺激低減劑之評估或選擇方法包括以下之(1)~(3)之步驟：(1)使受驗物質與可表現CES1之細胞接觸之步驟；(2)測定該細胞中之CES1之表現之步驟；及(3)基於(2)中所測定之結果，評估促進CES1之表現之受驗物質作為因對羥苯甲酸酯類所致之感覺刺激低減劑之步驟。
