A baby bottle holder for supporting a baby bottle in a manner that allows a baby to feed from a baby bottle. A substantially planar support frame has a bottom portion, a top portion with a rounded first side and a rounded second side with an opening configured to accept a portion of a baby bottle. A first side portion of the support frame is spaced apart from a second side portion, so that a baby can grasp one or both side portions. A bottle gripping element lines the opening. In one example, the bottle gripping element is a thin layer of rubbery material. In another example, the bottle gripping element includes a compliant seal portion adapted to accepting bottles of various diameters. In various examples, the frame includes rattles, movable elements such as rotatable wheels, or decorative elements such as “ears”.