Methods and Compositions for Improving Pial Collateral Circulation and Treating Blood Clotting Disorders

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专利权人:

Ohio State Innovation Foundation

发明人:

Chandan Sen,Cameron Rink,Sashwati Roy,Greg Christoforidis

申请号：

US14406402

公开号：

US20150139938A1

申请日:

2013.06.07

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention provides methods of promoting arteriogenesis in a subject. Embodiments include methods comprising: administering an effective dose of tocotrienol to the subject； causing an increase in Tissue Inhibitor of Metalloproteinase Metallopeptidase Inhibitor 1 (TIMP1) in vessels of cerebrovascular collateral circulation in the subject； attenuating the activity of Matrix Metalloproteinase-2 (MMP2)； thereby promoting arteriogenesis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/