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Tumor-inhibiting platinum (II) oxalate complex
专利权人:
ベルンハルト;ケプラー ケー. ベルンハルト;ケプラー;ケー.
发明人:
ケプラー バーナード
申请号:
JP2008315121
公开号:
JP5320049B2
申请日:
2008.12.11
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A tumor-inhibiting platinum (II) oxalate complex and its use as a therapeutic agent are provided, in particular as a tumor-inhibiting medicament. The complex may be compounds of the general formula (I), wherein the substituents R<;SUP>;1<;/SUP>;, R<;SUP>;1'<;/SUP>;, R<;SUP>;2<;/SUP>;, R<;SUP>;2'<;/SUP>;, R<;SUP>;3<;/SUP>;, R<;SUP>;3'<;/SUP>;, R<;SUP>;4<;/SUP>;, and R<;SUP>;4'<;/SUP>; are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl and unsubstituted or substituted alkylaryl radicals, the substituents R<;SUP>;5<;/SUP>;, R<;SUP>;5'<;/SUP>;, R<;SUP>;6<;/SUP>;, and R<;SUP>;6'<;/SUP>; are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, and unsubstituted or substituted alkenyl radicals, and wherein optionally in each case at least two of the substituents R<;SUP>;1<;/SUP>;, R<;SUP>;1'<;/SUP>;, R<;SUP>;2<;/SUP>;, R<;SUP>;2'<;/SUP>;, R<;SUP>;3<;/SUP>;, R<;SUP>;3'<;/SUP>;, R<;SUP>;4<;/SUP>;, and R<;SUP>;4'<;/SUP>; can form with one another at least one unsubstituted or substituted alkylene, unsubstituted or substituted alkenylene radical or an unsubstituted or substituted aromatic ring, and wherein optionally at least one of the carbon atoms of the cyclohexane ring bearing the substituents R<;SUP>;1<;/SUP>;, R<;SUP>;1'<;/SUP>;, R<;SUP>;2<;/SUP>;, R<;SUP>;2'<;/SUP>;, R<;SUP>;3<;/SUP>;, R<;SUP>;3'<;/SUP>;, R<;SUP>;4<;/SUP>;, and R<;SUP>;4'<;/SUP>; is replaced by a heteroatom, and if the heteroatom is oxygen, the substituents R<;SUP>;1<;/SUP>;, R<;SUP>;1'<;/SUP>;, R<;SUP>;2<;/SUP>;
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