The Board of Trustees of the Leland Stanford Junior University
发明人:
Daria Mochly-Rosen,Xin Qi,Nir Qvit
申请号：
US14988403
公开号：
US09730977B2
申请日:
2016.01.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.
