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COMPOSITION MÉDICINALE
专利权人:
FUJIFILM Toyama Chemical Co.; Ltd.
发明人:
OKADA, Kotaro,SAKATA, Yoshinori,TSUJIHATA, Shigetomo
申请号:
EP17885808
公开号:
EP3563845A4
申请日:
2017.12.28
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
An object of the present invention is to provide a solid pharmaceutical composition which suppresses the characteristic bitter taste of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and has a good storage stability of the-aforementioned compound or a salt thereof. The present invention provides a solid pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and a carboxylic acid whose solubility in water at 25°C is 50 g/100 g H<;sub>;2<;/sub>;O or less, wherein pH of a solution obtained when the solid pharmaceutical composition is dissolved or suspended in a 10 mmol/L KCl solution such that 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or the salt thereof is 1 mg/mL or 8.96 mg/mL is 4.8 or less.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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