Devices, systems, and techniques for monitoring vascular disease of a user are disclosed. In some examples, a wearable device for monitoring chronic venous insufficiency of a user may include a band configured to couple the wearable device to a leg of a user, a strain sensor configured to generate strain information indicative of changes in circumference of at least a portion of the leg, an activity sensor configured to generate activity information indicative of one or more of an orientation or a movement of the leg, and a processor configured to output user information indicative of the strain information and the activity information.