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COMPOSÉS DE PYRIMIDINE HYDROXY AMIDE COMME INHIBITEURS D'HISTONE DÉSACÉTYLASE
专利权人:
Acetylon Pharmaceuticals; Inc.
发明人:
申请号:
EP14852720.3
公开号:
EP3055299A4
申请日:
2014.10.09
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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