Disclosed herein is a stable antioxidant herbal composition of Lagenaria siceraria comprising: (i) microspheres containing about 70% to about 99%, ethanolic extract of Lagenaria siceraria fruits and (ii) optionally, at least one pharmaceutically/cosmetically acceptable excipient, and wherein, said microsphere is capable of prolonging the shelf-life of antioxidant activity of Lagenaria siceraria fruit extract for a period of at least 6 months at ambient temperature. Also discloses a process for preparing microsphere containing Lagenaria siceraria fruit extract and use antioxidant herbal composition in foot care and topical applications.