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SYSTÈMES ET PROCÉDÉS D'ADMINISTRATION D'AGENTS BIOLOGIQUEMENT ACTIFS PAR LE BIAIS DE SÉQUENCES VECTRICES DÉRIVÉES DE TOXINE BACTÉRIENNE
专利权人:
Mahmood, Tahir;Mrsny, Randall J.
发明人:
申请号:
EP11825567.8
公开号:
EP2616045B1
申请日:
2011.09.15
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics. The systems and methods described herein provide for: the ability to deliver macromolecule doses without injections; the ability to deliver cargo such as siRNA or antisense molecules into intracellular compartments where their activity is required; and the delivery of nanoparticles and dendrimer-based carriers across biological membranes.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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