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PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCER
专利权人:
ТОРЭЙ ИНДАСТРИЗ; ИНК. (JP)
发明人:
ОКАНО Фумиеси (JP),САИТО Таканори (JP),ИДО Такаеси (JP),СИМИДЗУ Масаки (JP)
申请号:
RU2011104709/15
公开号:
RU2011104709A
申请日:
2009.07.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition for treating and / or preventing cancer, comprising as an effective component an antibody or fragment thereof, wherein said antibody has immunoreactivity to CD179b protein having the amino acid sequence of SEQ ID NO: 3, or an amino acid sequence that is not less than 60% identical to the specified amino acid sequence or its fragment containing at least 7 adjacent amino acids. ! 2. The pharmaceutical composition according to claim 1, wherein said cancer is breast cancer, leukemia or lymphoma. ! 3. The pharmaceutical composition according to claim 1 or 2, wherein said antibody is a monoclonal antibody or a polyclonal antibody. ! 4. The pharmaceutical composition according to claim 1 or 2, wherein said antibody is a human antibody, a humanized antibody, a chimeric antibody, a single chain antibody, or a bispecific antibody. ! 5. The antibody containing the variable region of the heavy chain having the amino acid sequences of SEQ ID NO: 103, 104 and 102, and the variable region of the light chain having the amino acid sequences of SEQ ID NO: 106, 107 and 108, where the specified antibody has immunoreactivity with respect to protein CD179b. ! 6. The antibody containing the variable region of the heavy chain having the amino acid sequence of SEQ ID NO: 105, and the variable region of the light chain having the amino acid sequence of SEQ ID NO: 109, where the specified antibody has immunoreactivity against protein CD179b. ! 7. The antibody according to claim 5 or 6, which is a humanized antibody, a chimeric antibody, a single chain antibody, or a bispecific1. Фармацевтическая композиция для лечения и/или профилактики рака, содержащая в качестве эффективного компонента антитело или его фрагмент, где указанное антитело обладает иммунореактивностью по отношению к белку CD179b, имеющему аминокислотную последовательность SEQ ID NO:3, или аминокислотную последовательность, которая не менее чем на 60% идентична указанной аминокислотной последовател
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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