SUPURAN, CLAUDIU,DEDHAR, SHOUKAT,MCDONALD, PAUL C.,CARTA, FABRIZIO
申请号：
CA2841217
公开号：
CA2841217C
申请日:
2011.06.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Therapeutic sulfonamide compounds with the formula R-Q-Ar-SO2NH2 are disclosed, wherein R is an aryl, hetaryl, alkyl or cycloalkyl group, Q is the group -L(CH2)n-, wherein n = 0,1 or 2 and L is the group - NHCXNH-, -NHC(S)SNH-, -NHCONHCSNH- or -SO2NH-, X is O or S and Ar is a C6-C10 aromatic or a heteroaromatic group that contains at least one heteroatom of oxygen, nitrogen or sulphur, which compounds selectively inhibit CAIX and CAXII, and which are effective in inhibiting hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.
