The present invention relates to fusion polypeptides comprising polypeptides derived from Staphylococcus aureus antigens, as well as vectors constructs comprising nucleic acid molecules encoding the fusion polypeptides. More particularly, the fusion polypeptides comprise: (i) a first polypeptide, wherein the first polypeptide is an EapH1 polypeptide, or a derivative or variant thereof； and (ii) a second polypeptide, wherein the second polypeptide is an EapH2 polypeptide, or a derivative or variant thereof. The invention also relates to the use of these fusion polypeptides and vectors, inter alia, as immunogenic compositions, particularly as vaccine compositions.
