Provided are: methods for treating aging or an age-related condition, symptom or disease； methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss)； methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth)； methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/β-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/β-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative thereof as disclosed herein.加齢または加齢に伴う状態、症状または疾患の治療方法；毛髪の成長、再成長または色素沈着の促進（または脱毛の予防）の方法；真皮細胞におけるアデノシン受容体の発現を増加させる方法（毛髪の成長と組み合わせて）；美容的治療を含む、皮膚の状態若しくは疾患またはその少なくとも１つの症状（例えば、皺、色素沈着過剰、赤み、酒さ、乾燥、亀裂、張りの喪失、弾性の喪失、菲薄化、および活力の喪失）の治療方法；が提供される。該方法は、十分な量の開示されるＣＢＰ／カテニン（例えば、ＣＢＰ／β－カテニン）拮抗剤を投与することを含み、特にここで、投与は、適切な体性幹細胞集団における対称分裂と比較して、または適切な体性幹細胞集団における対称分裂を犠牲にして、非対称複製分裂の数を増加するのに十分な量および様式で行われる。【選択図】図１５
