Steven J. M. Jones,Oleksandr Yakovenko,Silvia Thoene,Pierre Yulmin Cheung,Jianghong An
申请号：
US14381588
公开号：
US20150154345A1
申请日:
2013.02.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.
