INC.;DUQUESNE UNIVERSITY OF THE HOLY SPIRIT;CABERTECH;CABERTECH, INC.
发明人:
MCGOWAN, KENNETH A.,GAWALT, ELLEN S.,PALCHESKO, RACHELLE
申请号：
EP12816970
公开号：
EP2739265A4
申请日:
2012.07.12
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention provides a functionalized composition and resulting functionalized body or prosthesis for in vitro and in vivo use comprising at least one calcium phosphate containing phase that is functionalized with a linker group comprising at least one of an organic acid molecule, a phosphonic acid, an amine, N,N-dicyclohexylcarbodiimide, and 3-maleimidopropionic acid N-hydroxysuccinimide ester, and combinations thereof, and one or more of a chemical and/or a biologically active moieties, wherein the linker group provides for a reactive location for the attachment of the chemical or biologically active moiety, or both, to the calcium phosphate containing phase, and optionally including an unmodified and/or modified calcium aluminate containing phase. Methods of manufacturing a functionalized artificial prosthesis and methods of repairing a bone, vertebrae, or tissue structures are provided.
