Abuse-deterrent oral solid dosage form comprising: an inner part comprising a drug susceptible to abuse and a pH-dependent polymer soluble in an acidic medium； an outer part, said part lacking a drug susceptible to abuse. An abusive deterrent oral comprising an immediate release form of the alkalinizing drug and a sustained release form of the alkalinizing drug, the sustained release form of the alkalinizing drug including an outer portion comprising the alkalinizing drug and a rate controlling excipient. Solid dosage form. In one aspect, the sustained release form of the alkalinizing agent is gradually released in 0.01 N hydrochloric acid in a sustained manner over a period of about 2 hours.乱用抑止経口固体投与形態であって、・乱用に陥りやすい薬物および酸性媒体に可溶性のｐＨ依存性ポリマーを含む内側部分、・外側部分であって、上記部分は、乱用に陥りやすい薬物を欠いており、アルカリ化薬の即時放出形態およびアルカリ化薬の徐放形態を含み、上記アルカリ化薬の徐放形態はアルカリ化薬および速度制御賦形剤を含む、外側部分、を含む、乱用抑止経口固体投与形態。一局面において、上記アルカリ化薬の徐放形態は、０．０１Ｎ塩酸中で約２時間の期間にわたって持続様式で徐々に放出される。
