An embolization agent for use with a therapeutic drug solution for treating diffuse diseases in a targeted tissue vessel of a patient and a process thereof is presented. This embolization agent comprises an inner core of a fast dispersing material having a diameter less than a predetermined size for the opening in the targeted tissue vessel and an outer sphere of an embolization material encompassing the inner core and having an initial diameter to occlude the initial opening in the targeted tissue vessel. During the treatment of the disease, the outer sphere of embolization material erodes at a predetermined rate, enhancing penetration of the embolization agent into the opening in the targeted tissue vessel. The inner core disperses into the targeted tissue vessel after becoming exposed by the erosion of the embolization material of the outer sphere.
