The invention relates to an ocular ionthophoretic device for supplying active principles comprising an active principle container placeable on an eye, an active principle solution in the container, an active electrode arranged in the container and a negative electrode, wherein the inventive device contains the active principles dissolved in non-saline water, the pH of said solution ranges from 6.5 to approximately 8.5, the active principles have a pKa ranging from 5.5 to approximately 9.5 and are bonded to an adjuvant such as dendrimers, polymers, nanoparticles, microspheres, liposomes or emulsions and have an ionic form whose valence is equal or greater than 1.
