Igor Mett;Hagar Kalinski;Elena Feinstein;Andrew E. Gelman;Svetlana Adamsky;Sharon Avkin-Nachum
发明人:
Andrew E. Gelman,Elena Feinstein,Svetlana Adamsky,Igor Mett,Hagar Kalinski,Sharon Avkin-Nachum
申请号：
US14002660
公开号：
US20140005253A1
申请日:
2012.03.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.
