The present invention provides a composition for treating acute urinary retention and reducing the recurrences rates in a male patient by administering a composition for treating acute urinary retention, said composition comprises at least one GnRH antagonist and at least one alpha blocker and/or at least one 5-alpha reductase inhibitor. Said composition provides a rapid reduction in the patient's testosterone level and returns the patient's testosterone level to near baseline in less than eight weeks. Also, the administration of the GnRH antagonist provides a significant reduction in the patient's acute urinary retention symptoms for a medication period of at least four months, six months or more.