DOUGLAS C. BLAND,PETER L. JOHNSON,RONALD JR. ROSS,TIMOTHY C. JOHNSON
申请号：
ARP130102306
公开号：
AR091610A1
申请日:
2013.06.28
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Processes for the preparation of certain N - oxides including functionalized Pyridine n-oxides of 2 - 5 - (1 - Alquiltio) alkyl pyridine.Claim 1, a process for the preparation of an n - Oxide 2 - 5 - (1 - Alquiltio) alkyl Pyridine according to formula (1), wherein l represents a Single Bond or r u00b9, s and L together form a Ring of 4, 5 or 6 members r u00b9 represents； c u2081 u208b u2084 R u00b2 alkyl； and R - individually represent Hydrogen, Methyl, Ethyl, fluoro,Chlorine or Bromine； n is an integer of 0 - 3； and y represents haloalquilo c u2081 u208b u2084； where: (i) an enamine according to formula (2) where r u00b9, R u00b2, r u00b3, L, and N are as defined above, and r u2074 and r u2075 independently represent alkyl c u2081 u208b u2088, alquenilo c u2082 u208b u2088 arilalq, Uilo c u2081 u208b u2088, haloalquilo c u2081 u208b u2088 alkoxyalkyl Esters c u2081 u208b u2088 alquilaminoalquilo c u2081 u208b u2088,,,Aryl or heteroaryl or r u2074 and r u2075 together with N represents a saturated or unsaturated Ring of 5 or 6 members, condenses with a B - unsaturated ketone, according to formula (3) where and are as defined above； and x u00b9 represents Halogen, or u2076, oso u2082r u2076, sr u2076, sor u2076 So u2082r u2076 nr u2077r u2078, or, where r u2076 c u2081 u208b u2088 represents Hydrogen, alkyl, arylalkyl alquenilo c u2082 u208b u2088, c u2081 u208b u2088, haloalquilo c u2081 u208b u2088,C u2081 u208b u2088 alquilaminoalquilo c u2081 u208b u2088 alkoxyalkyl esters, aryl or heteroaryl, and r u2077 and r u2078 independently represent Hydrogen, c u2081 u208b u2088 alquenilo c u2082 u208b u2088, alkyl, arylalkyl c u2081 u208b u2088, haloalquilo c u2081 u208b u2088 alkoxyalkyl Esters c u2081 u208b u2088 alquilaminoalquilo c u2081 u208b u2088,,,Aryl or heteroaryl or r u2077 and r u2078 together with N represents a saturated or unsaturated Ring of 5 or 6 members； to provide an intermediate Compound according to formula (4) where r u00b9, R u00b2, r u00b3, r u20
