Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine telenzepine atropine or derivatives thereof or salts thereof or analogs thereof or derivatives thereof and a pharmacologically acceptable carrier. The composition may be injectable or alternatively may be applied topically or alternatively may be delivered orally. A suitable topical composition may comprise a lotion a cream a gel or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
