Disclosed herein are amido compounds that form covalent bonds with Bruton’s tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.本文所揭露者為與布魯頓氏酪胺酸激酶(Btk)形成共價鍵的醯胺基化合物。亦描述Btk的不可逆抑制劑。亦揭露包括該些化合物之醫藥組成物。所揭露的是使用Btk抑制劑(單獨或與其它治療劑組合)用以治療自體免疫疾病或病狀、異種免疫疾病或病狀、癌症(包括淋巴瘤)、及發炎性疾病或病狀的方法。
