ANTICANCER ADJUVANT COMPOSITION CONTAINING RIP3 EXPRESSION PROMOTER AS ACTIVE INGREDIENT, METHOD FOR SCREENING FOR ANTICANCER ADJUVANT ENHANCING SENSITIVITY OF ANTICANCER DRUG BY PROMOTING RIP3 EXPRESSION, AND METHOD FOR MONITORING SENSITIVITY OF ANTICANCER DRUG
KIM, You Sun,KOO, Gi Bang,YUN, Jung Ho,KIM, Woo Jung,JO, Yu Na
申请号：
EP14882054
公开号：
EP3103475A4
申请日:
2014.11.25
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition for an anticancer adjuvant containing a receptor-interacting protein kinase-3 (RIP3) protein expression inducing agent or activator as an active ingredient. The present invention also provides a method for enhancing cancer cell death, comprising administering a RIP3 protein expression inducing agent or activator in combination with an anticancer drug to cancer cells. Additionally, the present invention relates to a method for screening an anticancer adjuvant which enhances anticancer drug sensitivity by promoting RIP3 expression and a method for monitoring anticancer drug sensitivity based on RIP3 expression. Therefore, in the case of patients lacking RIP3 expression, the use of a conventional chemotherapeutic agent after inducing RIP3 expression by pretreatment with a demethylating agent may be an effective therapeutic strategy. Also, it is expected that monitoring anticancer drug sensitivity and screening an anticancer adjuvant that enhances anticancer drug sensitivity in anticancer therapy may be an effective strategy.
