PIECZYKOLAN JERZY SZCZEPAN,PAWLAK SEBASTIAN DOMINIK,&ZdotEREK BART&LstrokOMIEJ MACIEJ,RÓZGA PIOTR KAMIL,SZAW&LstrokOWSKA URSZULA MARTA
申请号：
NZ61735312
公开号：
NZ617353A
申请日:
2012.04.19
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
A fusion protein comprising: domain (a) which comprises the functional fragment of a soluble hTRAIL protein sequence starting with an amino acid in a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity and at least one domain (b) which is the sequence of an effector peptide having anti-proliferative activity against tumour cells, and wherein the sequence of domain (b) is attached at the C-terminus and/or at the N-terminus of domain (a). Also disclosed is the use of said fusion protein for the treatment of cancer.
